Two cDNA sequences encoding Drosophila Ace-orthologous and -paralogous acetylcholinesterase precursors (AO- and AP-AChE precursors, respectively), were identified from the body louse, Pediculus humanus humanus L. In vitro inhibition studies with an insecticide-susceptible body louse strain exhibited a simplex inhibitory response of AChE. The I50 values of fenitroxon and carbaryl were estimated to be 2.2 and 1.9 μM for the susceptible lice, respectively. The mRNA level of AP-AChE gene was 3.1- and 9.3-fold higher than that of AO-AChE gene in the abdomen and the combined parts of the head and thorax, respectively, suggesting, due to its abundance, the potential significance of the AP-AChE isoform in Pediculus human lice in association with the efficacy of AChE-targeting pediculicides.
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1 January 2007
Molecular Characterization of Two Acetylcholinesterase cDNAs in Pediculus Human Lice
Si-Woo Lee,
Shinji Kasai,
Osamu Komagata,
Mutsuo Kobayashi,
Noriaki Agui,
Yoshiaki Kono,
Takashi Tomita
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Journal of Medical Entomology
Vol. 44 • No. 1
January 2007
Vol. 44 • No. 1
January 2007
acetylcholinesterase
insecticide resistance
pediculicide efficacy
Pediculus humanus humanus